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Addresses #2920 NTR placental villous stroma #2949

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merged 15 commits into from
Jan 5, 2024

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Fixes #2920 NTR placental villous stroma

Fixes #2920 NTR placental villous stroma
@aleixpuigb aleixpuigb requested a review from a user July 4, 2023 13:23
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Defer to requester's review of content.

The text and logical definitions use the term "chorionic villus" while the label is 'placental villous stroma', which could potentially cause user confusion. Should the label be updated and / or synonym added?

@aleixpuigb aleixpuigb requested a review from emquardokus July 4, 2023 14:16
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github-actions bot commented Aug 4, 2023

This PR has not seen any activity in the past month; if nobody comments or reviews it in the next week, the PR creator will be allowed to proceed with merging without explicit approval, should they wish to do so.

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This PR has not seen any activity in the past month; if nobody comments or reviews it in the next week, the PR creator will be allowed to proceed with merging without explicit approval, should they wish to do so.

@aleixpuigb
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The text and logical definitions use the term "chorionic villus" while the label is 'placental villous stroma', which could potentially cause user confusion. Should the label be updated and / or synonym added?

@emquardokus I have seen "chorionic villous stroma" and "placental villous stroma" in the literature without a clear preference. Is there a reason for the term to be labeled "placental villous stroma"?

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@aleixpuigb
my original NTR had this paper and definition: I'm not sure why the definition you have uses chorionic villus?

Definition from paper: The placental villous stroma is a connective tissue layer that supports the fetal capillaries and villous trophoblast.

Definition (free text, please give PubMed ID)
PMID: 31512233
Palaiologou E, Etter O, Goggin P, Chatelet DS, Johnston DA, Lofthouse EM, Doherty R, Pearson-Farr J, Sengers BG, Torrens C, Cleal JK, Page AM, Lewis RM. Human placental villi contain stromal macrovesicles associated with networks of stellate cells. J Anat. 2020 Jan;236(1):132-141. doi: 10.1111/joa.13082. Epub 2019 Sep 11. PMID: 31512233; PMCID: PMC6904625.

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Thank you for your answer.

The reason behind having "chorionic villus" in the definition is to align with the logical definition. What I can do is to include placental villus in brackets for clarification:

A stroma that is part of a chorionic villus (placental villous). A placental villous stroma supports the fetal capillaries and villous trophoblast.

@aleixpuigb aleixpuigb merged commit b7d189c into master Jan 5, 2024
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@aleixpuigb aleixpuigb deleted the 2920_NTR_placental_villous_stroma branch January 5, 2024 11:34
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NTR: placental villous stroma
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